| Women's Nike Run Defy — Black/Anthracite | Jul 14, 2026 | $65 | HM9593-003 |
| Women's Nike Run Defy — Light Orewood Brown/Cave Stone/White/College Grey | Jul 14, 2026 | $65 · Now $58.97 | HM9593-100 |
| Women's Nike Run Defy — White/Smoke Grey/Black | Jul 14, 2026 | $65 · Now $49.97 | HM9593-101 |
| Women's Nike Run Defy — Black/Hyper Pink/Pink Foam/Elemental Pink | Apr 24, 2026 | $65 | HM9593-001 |
| Women's Nike Run Defy — White/Football Grey/Work Blue/Blue Void | Apr 20, 2026 | $65 · Now $41.97 | HM9593-109 |
| Women's Nike Run Defy — Summit White/White/Malachite/Metallic Silver | Mar 20, 2026 | $65 | HM9593-122 |
| Women's Nike Run Defy — Sail/Summit White/Chalk/White | Jan 20, 2026 | $65 | HM9593-107 |
| Women's Nike Run Defy — Particle Rose/Sail/Tattoo/Hydrogen Blue | Dec 20, 2025 | $65 | HM9593-606 |
| Nike Run Defy — Black/Dark Hazel/Light Khaki/Black | Dec 20, 2025 | $65 | HM9594-010 |
| Nike Run Defy — White/Black | Dec 20, 2025 | $65 | HM9594-102 |
| Nike Run Defy — Summit White/Turf Orange/White/Bright Crimson | Dec 20, 2025 | $53 | HM9594-103 |
| Nike Run Defy — White/Glacier Blue/Green Strike/Black | Dec 20, 2025 | $65 | HM9594-112 |
| Nike Run Defy — Black/Anthracite | Oct 14, 2025 | $65 | HM9594-002 |
| Women's Nike Run Defy — Ghost/Summit White/Football Grey/Midnight Navy | Oct 1, 2025 | $65 | HM9593-005 |
| Nike Run Defy — Wolf Grey/White/Iron Grey/Black | Oct 1, 2025 | $65 | HM9594-003 |
| Nike Run Defy "White Pure Platinum" — White/Black/Pure Platinum | Jul 6, 2025 | $60 | HM9594-100 |
| Nike Run Defy "Light Army Iron Grey" — Light Army/Iron Grey/White | Jul 6, 2025 | $60 | HM9594-300 |
| Nike Run Defy "University Blue" — University Blue/White/Black | Jul 6, 2025 | $60 | HM9594-400 |
| Nike Run Defy "Deep Royal Blue" — Deep Royal Blue/World Indigo/Black | Jul 6, 2025 | $60 | HM9594-401 |
| Nike Run Defy — Black/White | Jun 20, 2025 | $65 | HM9594-004 |
| Women's Nike Run Defy — White/Black/Pure Platinum | Apr 23, 2025 | $65 · Now $52.97 | HM9593-103 |
| Women's Nike Run Defy — Black/Wolf Grey/White | Apr 20, 2025 | $65 | HM9593-002 |
| Women's Nike Run Defy — Dark Smoke Grey/Aluminum/Football Grey/White | | $65 | HM9593-007 |
| Women's Nike Run Defy — Elemental Pink/Silt Red/Black/White | | $65 | HM9593-600 |
| Nike Wmns Run Defy "Sweet Beet" — Pink | | $65 | HM9593-603 |
| Nike Run Defy "Wolf Grey Bright Crimson" — Wolf Grey/Black/White | | $65 | HM9594-005 |
| Nike Run Defy "Phantom Seaweed" — Phantom/Sail/College Grey | | $65 | HM9594-007 |
| Nike Run Defy "Cannon Mint Foam" — Cannon/Mint Foam/Summit White | | $65 | HM9594-008 |
| Nike Run Defy "Pure Platinum Blue Hero" — Pure Platinum/Aluminum/White | | $65 | HM9594-009 |
| Nike Run Defy "Black White" — Summit White/Black | | $60 | HM9594-122 |
| Nike Run Defy — Filbert/Light Khaki/Dark Hazel/Sail | | $65 | HM9594-200 |